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. 2017 Oct 16;9(12):1629–1645. doi: 10.15252/emmm.201607445

Figure 2. Macrophages invading growing glioma are bone marrow derived.

Figure 2

  1. F4/80 immunohistochemistry on a section of 5‐week growth glioma implanted in ROSAmT/mG ::Pdgfb‐iCre mouse (50‐μm depth stack).
  2. Two‐photon live imaging of LifeAct‐GFP bone marrow transplantation in 5‐week implanted glioma in ROSAmT/mG mice (100‐μm depth stack).
  3. Two‐photon live imaging of LifeAct‐GFP bone marrow transplantation in 3‐ and 5‐week implanted glioma in ROSAmT/mG. Macrophages relocate close to blood vessels during glioma growth (50‐μm depth stack; n = 4 mice).
Data information: Statistical analysis: (C) t‐test. Error bars: mean ± SD. Scale bars: (A) 150 μm; (B) upper panels: 70 μm; (B) lower panels: 280 μm; (C) 100 μm.