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. 2017 Nov 30;9:106. doi: 10.1186/s13073-017-0494-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Manhattan plots for gene-based CNV meta-analysis. The results for deletion CNVs are shown in a and those for duplication CNVs are shown in b. The − log10(P value) of each gene (y-axis) in the meta-analysis is plotted against the genomic position (x-axis). Significant loci are indicated on the plot. The locus of 22q11.22 is a known locus for neuropsychiatric disorders and 9p24.3 is a novel locus at which each CNV carrier has been validated by manual visual review of BAF and LRR plots and qPCR experiments