Table 1.
Effect of 4 weeks of linagliptin treatment on body weight, tibia length, and organ weights in klotho (−/−) mice
| Control (n = 10) |
Linagliptin (n = 14) |
Statistical significance | |
|---|---|---|---|
| Body weight (g) | 9.9 ± 0.3 | 11.1 ± 0.3 | P < 0.01 |
| Tibia length (mm) | 15.1 ± 0.2 | 15.3 ± 0.1 | NS |
| Cerebrum/TL (mg/mm) | 19.3 ± 0.2 | 19.0 ± 0.2 | NS |
| Cerebellum/TL (mg/mm) | 3.6 ± 0.1 | 3.6 ± 0.1 | NS |
| Left ventricle/TL (mg/mm) | 2.5 ± 0.1 | 2.6 ± 0.1 | NS |
| Right ventricle/TL (mg/mm) | 0.6 ± 0.03 | 0.7 ± 0.04 | NS |
| Kidney/TL (mg/mm) | 4.6 ± 0.2 | 5.2 ± 0.2 | P < 0.05 |
| Subcutaneous fat/TL (mg/mm) | 2.8 ± 0.6 | 3.9 ± 0.5 | NS |
| Visceral fat/TL (mg/mm) | 3.1 ± 0.5 | 4.3 ± 0.7 | NS |
| Gastrocnemius muscle/TL (mg/mm) | 2.9 ± 0.1 | 3.4 ± 0.1 | P < 0.01 |
Values are mean ± SEM. Statistical analysis was performed by non-paired t test or Mann–Whitney U test
Control, control group; Linagliptin, linagliptin-treated group; TL, tibia length; NS, not significant