Table 1.
Associations between miRNAs expression levels in T cells and clinical parameters in rheumatoid arthritis patients
| miRNA | Age (per 10 years | Sex (male/female) | CRP (mg/dL) | ACPAs (per 10 IU/mL) | Positivity of RF (yes/no) | Sulfalsalazine usage (yes/no) | MTX dosage (mg/week) | Leflunomide usage (yes/no) | Steroid dosage equivalent to perdnisolone (mg/day) | Biologic agenta usage (yes/no) |
|---|---|---|---|---|---|---|---|---|---|---|
| miR-139-3p | 0.07 (0.816) | –0.35 (0.732) | –0.26 (0.460) | -0.03 (0.373) | –1.73 (0.031) | –0.50 (0.683) | 0.06 (0.581) | 0.51 (0.508) | 0.50 (0.054) | 2.02 (0.007) |
| miR-204 | 0.15 (0.615) | –1.36 (0.128) | –0.33 (0.285) | -0.04 (0.152) | –0.63 (0.385) | –1.27 (0.233) | –0.06 (0.484) | 0.26 (0.700) | 0.09 (0.707) | 2.04 (0.002) |
| miR-214 | –0.26 (0.344) | –0.05 (0.949) | –0.72 (0.010) | -0.01 (0.515) | –0.96 (0.158) | –1.56 (0.116) | –0.10 (0.287) | 1.02 (0.107) | 0.03 (0.900) | 1.50 (0.016) |
| miR-383 | –0.03 (0.891) | –0.82 (0.309) | 0.11 (0.687) | 0.02 (0.497) | –0.12 (0.854) | –2.72 (0.003) | –0.22 (0.009) | –0.26 (0.672) | –0.53 (0.009) | 0.41 (0.507) |
| miR-524-5p | –0.39 (0.307) | –0.93 (0.435) | –0.41 (0.313) | 0.00 (0.921) | –1.07 (0.266) | –1.32 (0.353) | –0.07 (0.568) | 0.69 (0.447) | 0.09 (0.775) | 0.63 (0.488) |
| miR-548d-3p | –0.19 (0.494) | –0.14 (0.870) | –0.45 (0.123) | 0.05 (0.051) | 0.14 (0.845) | –1.66 (0.098) | –0.01 (0.880) | –0.43 (0.505) | 0.02 (0.926) | 0.42 (0.524) |
| miR-760 | –0.40 (0.253) | 0.29 (0.795) | –0.23 (0.553) | -0.01 (0.780) | –1.08 (0.226) | –1.56 (0.234) | –0.08 (0.485) | 1.73 (0.035) | 0.51 (0.074) | 2.32 (0.004) |
| miR-877 | –0.48 (0.235) | –0.27 (0.833) | –0.04 (0.922) | -0.02 (0.554) | 0.05 (0.965) | –0.32 (0.830) | –0.08 (0.563) | 1.28 (0.175) | 0.36 (0.266) | 1.30 (0.174) |
Values shown are correlation coefficients and (p values) from simple linear regression, and those in bold represent p < 0.05
ACPAs anti-citrullinated protein antibodies, CRP C-reactive protein, miRNA microRNAs, MTX methotrexate, RF rheumatoid factor
aBiologic agent including: tumor necrosis factor antagonists, abatacept, and tocilizumab
Values shown are correlation coefficients and (p values) from simple linear regression, and those in bold represent p < 0.05