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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Sci Signal. 2016 Aug 23;9(442):ra83. doi: 10.1126/scisignal.aaf5642

Fig. 4. Altered DNA methylation status from shRNA-mediated TET3 knockdown regulates the expression of genes associated with ion channel activity.

Fig. 4

(A) Gene ontology analysis of differentially down-regulated genes in control versus TET3 knockdown neurons. (B) Heatmap showing the relative expression of all voltage and Ca2+-activated K+ channels in TET3 knockdown neurons. (C) Heatmap showing the relative expression of all voltage-gated Na+ channels in TET3 knockdown neurons. (D) Heat-map showing the relative expression of all voltage-and ligand-gated Ca2+ channels in TET3 knockdown neurons. (A to D) Data are based on RNA-seq analyses of hippocampal neurons expressing an shRNA against Tet3 (sh-Tet3) compared to those expressing a control shRNA (n = 3 samples each; GSE67245). Asterisks indicate genes that exhibited significant differential expression in TET3 knockdown neurons [false discovery rate (FDR) < 0.05].