Table 1.

Passive membrane properties of the analyzed neurons exposed to various treatments.

Figure	Treatment	n	Vm (mV)	Rinput (megohms)	τ(ms)	Cm (pF)
1	CTL	16	−57.6 ± 1.1	570 ± 39	62.7 ± 4.7	58.3 ± 2.6
	RG108	16	−62.1 ± 1.7*	575 ± 52	63.6 ± 5.9	66.7 ± 5.6
2	CTL	7	−60.1 ± 1.3	606 ± 75	63.3 ± 5.6	65.7 ± 4.4
	RG108 + APV	5	−60.4 ± 3.2	478 ± 80	66.4 ± 6.7	67.2 ± 8.3
	RG108 + NBQX + APV	7	−58.4 ± 2.1	527 ± 50	67.9 ± 7.4	69.2 ± 6.3
	RG108 + TTX	7	−58.7 ± 1.9	590 ± 96	77.9 ± 13.4	58.2 ± 5.8
3	CTL	11	−59.3 ± 1.2	589 ± 59	61.1 ± 4.7	60.9 ± 3.6
	RG108 + ActD	4	−59.3 ± 4.1	579 ± 153	64.1 ± 10.6	46.3 ± 2.0
	Scrambled CTL	6	−57.3 ± 1.5	594 ± 30	62.6 ± 4.1	67.0 ± 5.4
	Tet1 ASO + RG108	7	−61.0 ± 1.7	619 ± 121	60.8 ± 5.2	52.7 ± 7.2
5	CTL	10	−59.0 ± 1.3	621 ± 53	62.2 ± 4.7	55.6 ± 5.1
	RG108	13	−62.6 ± 1.2	599 ± 59	62.9 ± 6.1	60.7 ± 3.7
6 (A to E)	Scrambled CTL	12	−56.8 ± 1.1	516 ± 32	59.5 ± 3.9	55.5 ± 4.2
	Dnmt1 ASO	9	−58.9 ± 1.2	613 ± 83	61.0 ± 4.6	56.9 ± 7.4
	Dnmt3a ASO	7	−60.7 ± 2.0	626 ± 61	66.6 ± 7.2	50.4 ± 3.5
6 (F to H)	Scrambled CTL	8	−57.0 ± 1.0	541 ± 35	56.8 ± 4.1	60.8 ± 4.8
	Dnmt1 ASO	5	−58.4 ± 2.0	507 ± 22	55.0 ± 4.5	65.4 ± 11.6
	Dnmt3a ASO	5	−63.4 ± 2.0	670 ± 71	70.3 ± 9.3	55.2 ± 8.1
7 (A and B, and E and F)	CTL	8	−56.4 ± 1.0	634 ± 54	63.0 ± 5.8	50.4 ± 5.0
	CTL + apamin	5	−58.4 ± 3.0	704 ± 41	73.3 ± 4.3	54.9 ± 5.3
	RG108	10	−62.0 ± 1.4	610 ± 68	61.6 ± 6.5	56.5 ± 2.8
	RG108 + apamin	4	−59.8 ± 4.0	683 ± 110	67.8 ± 5.7	58.1 ± 4.0
7 (C and D, and G and H)	CTL	18	−58.1 ± 1.1	570 ± 38	62.3 ± 4.2	60.3 ± 2.7
	CTL + apamin	5	−58.4 ± 3.0	704 ± 41	73.3 ± 4.3	54.9 ± 5.3
	RG108	19	−62.7 ± 1.5	575 ± 48	63.5 ± 5.4	67.1 ± 5.1
	RG108 + apamin	4	−59.8 ± 4.0	683 ± 110	67.8 ± 5.7	58.1 ± 4.0

All values are means ± SEM.

^*P < 0.05, Student’ t test. n, number of cells; V_m, resting membrane potential; R_input, input resistance; τ, membrane time constant; C_m, membrane capacitance; ActD, actinomycin D.