Table 2.
Single AP waveform characteristics of control and RG108-treated neurons.
| Treatment (n) | CTL (10) | RG108 (13) |
|---|---|---|
| AP waveform | ||
| Vthr (mV) | −45.1 ± 0.8 | −48.8 ± 0.7* |
| Maximal depolarization rate (mV/ms) | 75.4 ± 4.2 | 80.9 ± 3.7 |
| Amplitude (mV) | 75.0 ± 2.4 | 80.0 ± 1.8 |
| Maximal repolarization rate (mV/ms) | 32.5 ± 3.4 | 32.5 ± 2.7 |
| One-half width (ms) | 2.5 ± 0.2 | 2.5 ± 0.1 |
| fAHP (mV) | −13.0 ± 1.1 | −12.3 ± 1.2 |
| mAHP (mV) | −21.2 ± 1.1 | −17.2 ± 1.0* |
| Time-to-peak AHP (ms) | 41.5 ± 3.0 | 38.6 ± 2.5 |
These values represent the neurons used for Fig. 5. All values are means ± SEM.
*
P < 0.05, Student’s t test. n, number of cells; Vthr, voltage threshold.