Table 3.
Treatment (n) | Scrambled CTL (9) | Dnmt1 ASO (5) | Dnmt3a ASO (5) |
---|---|---|---|
AP waveform | |||
Vthr (mV) | −45.2 ± 1.1 | −48.4 ± 1.6 | −49.6 ± 1.6 |
Maximal depolarization rate (mV/ms) | 78.6 ± 4.7 | 81.4 ± 6.5 | 82.0 ± 2.5 |
Amplitude (mV) | 75.8 ± 3.3 | 79.5 ± 3.1 | 82.1 ± 1.8 |
Maximal repolarization rate (mV/ms) | 28.8 ± 7.6 | 37.8 ± 5.4 | 31.4 ± 4.5 |
One-half width (ms) | 2.2 ± 0.1 | 2.2 ± 0.2 | 2.6 ± 1.8 |
fAHP (mV) | −14.9 ± 0.7 | −12.4 ± 1.0 | −12.1 ± 0.8* |
mAHP (mV) | −22.8 ± 1.1 | −18.8 ± 1.0* | −16.2 ± 1.0* |
Time-to-peak AHP (ms) | 37.9 ± 2.2 | 38.6 ± 3.3 | 41.8 ± 1.3 |
All values are means ± SEM.
P < 0.05, one-way ANOVA followed by Dunnett’s test. n, number of cells.