Table 4.
Treatment (n) | CTL (8) | CTL + apamin (5) | RG108 (10) | RG108 + apamin (4) |
---|---|---|---|---|
AP waveform | ||||
Vthr (mV) | −45.1 ± 1.0 | 49.0 ± 0.9 | −49.1 ± 0.6 | −47.3 ± 2.1 |
Maximal depolarization rate (mV/ms) | 75.0 ± 4.2 | 78.2 ± 3.7 | 80.7 ± 4.5 | 73.0 ± 8.8 |
Amplitude (mV) | 73.0 ± 2.4 | 78.3 ± 2.5 | 79.0 ± 2.0 | 72.8 ± 4.7 |
Maximal repolarization rate (mV/ms) | 33.8 ± 3.8 | 28.4 ± 4.5 | 34.0 ± 3.4 | 28.5 ± 4.5 |
One-half width (ms) | 2.3 ± 0.1 | 2.8 ± 0.4 | 2.4 ± 0.2 | 2.5 ± 0.2 |
fAHP (mV) | −13.5 ± 0.9 | −10.6 ± 1.2 | −9.4 ± 3.2 | −11.3 ± 2.4 |
mAHP (mV) | −22.7 ± 0.4 | −17.5 ± 1.3* | 17.0 ± 1.1 | 17.3 ± 2.2 |
Time-to-peak (ms) | 40.3 ± 3.7 | 37.6 ± 3.0 | 41.1 ± 3.0 | 43.0 ± 2.8 |
All values are means ± SEM.
P < 0.05, Student’s t test. n, number of cells.