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Acute administration of SKA-31 and sodium nitroprusside (SNP) reduce systemic vascular resistance (SVR). Panel A displays absolute values for SVR recorded prior to a given drug infusion and following SKA-31 and SNP infusions at the indicated dosages. For the latter data, measurements were taken during the peak change in SVR. Panel B displays the calculated percentage change in systemic vascular resistance under each infusion condition compared with the preceding control.
