DKP/TRAM(N = 152)	DKP (N = 151)	TRAM (N = 150)	Placebo (N = 153)
TOTPAR2	Responder, n (%)	91 (60)	69 (46)	58 (39)	50 (33)
	Non-Responder, n (%)	60 (40)	82 (54)	91 (61)	103 (67)
	Treatment comparisons p-value
	DKP/TRAM vs. DKP	0.011
	DKP/TRAM vs. TRAM	<0.001
	DKP vs. Placebo	0.020
	TRAM vs. Placebo	0.258
TOTPAR4	Responder, n (%)	99 (65)	80 (53)	65 (43)	49 (32)
	Non-Responder, n (%)	52 (34)	71 (47)	84 (56)	104 (68)
	Treatment comparisons p-value
	DKP/TRAM vs. DKP	0.026
	DKP/TRAM vs. TRAM	<0.001
	DKP vs. Placebo	<0.001
	TRAM vs. Placebo	0.038
TOTPAR6	Responder, n (%)	105 (69)	72 (48)	64 (43)	49 (32)
	Non-Responder, n (%)	46 (30)	79 (52)	85 (57)	104 (68)
	Treatment comparisons p-value
	DKP/TRAM vs. DKP	<0.001
	DKP/TRAM vs. TRAM	<0.001
	DKP vs. Placebo	0.005
	TRAM vs. Placebo	0.050
TOTPAR8	Responder, n (%)	100 (66)	72 (48)	66 (44)	47 (31)
	Non-Responder, n (%)	51 (34)	79 (52)	83 (55)	106 (69)
	Treatment comparisons p-value
	DKP/TRAM vs. DKP	0.001
	DKP/TRAM vs. TRAM	<0.001
	DKP vs. Placebo	0.002
	TRAM vs. Placebo	0.015