Figure 3.

Current state of the desmin interactome. Known direct connections of desmin with proteins of different cardiomyocyte compartments are presented. The different colors indicate the corresponding compartment that the desmin-associated proteins are localized to (see key, lower right). The positions of these compartments are indicated in the typical cardiomyocyte diagram shown as a neutral background (adapted from Capetanaki et al. 2015). Proteins localized in multiple compartments are shown with the corresponding multiple colors. Only a few proteins (dysbindin, calcineurin, and RIIa) are shown that connect indirectly to desmin—all through myospryn. RIIa, regulatory subunit of cAMP-dependent kinase; VDAC, voltage-dependent anion channel.