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. 2017 Sep 20;2(9):959–966. doi: 10.1001/jamacardio.2017.2289

Figure 4. Use of Lipid-Lowering Treatment (LLT) With Full Treatment Intensification Across All Scenarios.

Figure 4.

Scenarios are ordered by increasing use of proprotein convertase subtilisin/kexin type 9 inhibitor therapy (for definition of scenarios, see Scenario Analyses subsection of the Methods). Scenario A includes reduction of low-density lipoprotein cholesterol (LDL-C) levels to less than 70 mg/dL for all patients and LLT with alirocumab (ALI) as third-line therapy after statins and add-on ezetimibe (EZE). Scenarios B1-B4, C, and D are described in Figure 3. Scenarios A and C used ALI as third-line therapy after statins and add-on EZE. Other scenarios removed EZE before adding ALI if goal LDL-C level was not achieved. ALI75 indicates alirocumab, 75 mg; ALI150, alirocumab, 150 mg; HIS, high-intensity statin; and MIS, moderate-to-low intensity statin. To convert LDL-C levels to millimoles per liter, multiply by 0.0259.