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. 2017 Nov 9;3(11):1487–1494. doi: 10.1001/jamaoncol.2017.0973

Figure 1. Cumulative Incidence of Treatment Failures Across Subsites.

Figure 1.

A, Local treatment failure. B, Regional treatment failure. C, Distant failure. D, Overall survival across subsites. Compared with oropharyngeal carcinoma (OPC), oral cavity carcinoma (OCC) demonstrated the highest cumulative incidence of local treatment failure (hazard ratio [HR], 5.2; 95% CI, 3.1-8.6; P < .001), followed by laryngeal carcinoma (LC) (HR, 2.6; 95% CI, 1.4-4.9; P = .004) and hypopharyngeal carcinoma (HPC) (HR, 2.5; 95% CI, 1.0-6.3; P = .06). Compared with OPC, OCC also demonstrated the highest cumulative incidence of regional treatment failure (HR, 2.2; 95% CI, 1.0-45; P = .04), followed by HPC (HR, 1.6; 95% CI, 0.5-5.1; P = .40) and LC (HR, 1.4, 95% CI, 0.6-3.3; P = .40). Hypopharyngeal carcinoma demonstrated the highest incidence of distant treatment failure compared with OPC (HR, 2.6; 95% CI, 1.5-4.6), followed by LC (HR, 1.5; 95% CI, 0.9-2.4; P = .08) and OCC (HR, 1.3; 95% CI, 0.8-2.2; P = .31). Overall survival was significantly longer for patients with OPC positive for human papillomavirus (HPV) or p16 compared with all other subsites combined (HR, 0.45; 95% CI, 0.36-0.57; P < .001).