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. 2017 Nov 9;3(11):1487–1494. doi: 10.1001/jamaoncol.2017.0973

Table. Univariate and Multivariate Analyses of Predictors of Death Following Locoregional Failure or Distant Metastasis.

Variable Univariate Analysis Multivariate Analysis
HR (95% CI) P Value HR (95% CI) P Value
Death following locoregional failure
KPS >70 0.34 (0.18-0.59) <.001 0.46 (0.26-0.81) .007
Age <70 y 0.62 (0.40-0.96) .03 0.74 (0.47-1.14) .17
Subsite (oral cavity vs other) 1.40 (0.91-2.15) .13 NA NA
Salvage surgery 0.44 (0.30-0.64) <.001 0.51 (0.34-0.77) .001
Salvage re-irradiation 0.54 (0.30-0.96) .04 0.72 (0.40-1.31) .29
Time to locoregional failure 0.99 (0.97-1.00) .10 NA NA
Death following metastasis
KPS >70 0.28 (0.18-0.42) <.001 0.39 (0.25-0.61) <.001
Age <70 y 0.65 (0.39-1.07) .09 NA NA
Solitary metastatic tumor 0.34 (0.17-0.65) .001 0.32 (0.16-0.63) .001
Cetuximab treatment 0.54 (0.36-0.80) .002 0.48 (0.31-0.73) .001
Subsite (oral cavity vs other) 3.85 (2.26-6.54) <.001 3.66 (1.98-6.80) <.001
Time to metastasis 0.97 (0.95-0.99) .002 0.98 (0.96-1.00) .05
Organ of metastasis (lung vs other) 0.72 (0.45-1.17) .19 NA NA

Abbreviations: HR, hazard ratio; KPS, Karnofsky performance status; NA, not applicable.