Table. Univariate and Multivariate Analyses of Predictors of Death Following Locoregional Failure or Distant Metastasis.
| Variable | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Death following locoregional failure | ||||
| KPS >70 | 0.34 (0.18-0.59) | <.001 | 0.46 (0.26-0.81) | .007 |
| Age <70 y | 0.62 (0.40-0.96) | .03 | 0.74 (0.47-1.14) | .17 |
| Subsite (oral cavity vs other) | 1.40 (0.91-2.15) | .13 | NA | NA |
| Salvage surgery | 0.44 (0.30-0.64) | <.001 | 0.51 (0.34-0.77) | .001 |
| Salvage re-irradiation | 0.54 (0.30-0.96) | .04 | 0.72 (0.40-1.31) | .29 |
| Time to locoregional failure | 0.99 (0.97-1.00) | .10 | NA | NA |
| Death following metastasis | ||||
| KPS >70 | 0.28 (0.18-0.42) | <.001 | 0.39 (0.25-0.61) | <.001 |
| Age <70 y | 0.65 (0.39-1.07) | .09 | NA | NA |
| Solitary metastatic tumor | 0.34 (0.17-0.65) | .001 | 0.32 (0.16-0.63) | .001 |
| Cetuximab treatment | 0.54 (0.36-0.80) | .002 | 0.48 (0.31-0.73) | .001 |
| Subsite (oral cavity vs other) | 3.85 (2.26-6.54) | <.001 | 3.66 (1.98-6.80) | <.001 |
| Time to metastasis | 0.97 (0.95-0.99) | .002 | 0.98 (0.96-1.00) | .05 |
| Organ of metastasis (lung vs other) | 0.72 (0.45-1.17) | .19 | NA | NA |
Abbreviations: HR, hazard ratio; KPS, Karnofsky performance status; NA, not applicable.