Table 3. Generalized Linear Modeling Analysis Results With GEE Solution for the AGRE Family Data Set Using Samples from MDS Cluster 1a.
| Covariate | Total, No. (%) (N = 3376)b | Patients With ASD, No. (%) (n = 1356)b | OR (95% CI) | P Value | Bonferroni | Benjamini-Hochberg |
|---|---|---|---|---|---|---|
| Intercept | NA | NA | 0.51 (0.39-0.65) | <.001 | <.001 | <.001 |
| Haplogroupc | ||||||
| A | 67 (2.0) | 33 (2.4) | 2.95 (1.92-4.52) | <.001 | <.001 | <.001 |
| I | 68 (2.0) | 27 (2.0) | 2.27 (1.35-3.81) | .002 | .03 | .008 |
| J | 354 (10.5) | 149 (11.0) | 2.22 (1.59-3.11) | <.001 | <.001 | <.001 |
| K | 251 (7.4) | 97 (7.2) | 1.94 (1.39-2.69) | <.001 | .001 | <.001 |
| L | 69 (2.0) | 29 (2.1) | 1.81 (1.03-3.17) | .04 | .49 | .08 |
| M | 67 (2.0) | 36 (2.7) | 3.14 (2.08-4.75) | <.001 | <.001 | <.001 |
| N+ | 20 (0.6) | 11 (0.8) | 4.52 (1.96-10.41) | <.001 | .005 | .002 |
| O-X | 50 (1.5) | 19 (1.4) | 2.01 (1.21-3.34) | .007 | .09 | .02 |
| T | 292 (8.6) | 108 (8.0) | 1.87 (1.34-2.61) | <.001 | .003 | .001 |
| U | 467 (13.8) | 187 (13.8) | 2.07 (1.49-2.88) | <.001 | <.001 | <.001 |
| W | 74 (2.2) | 30 (2.2) | 1.4 (0.81-2.4) | .22 | >.99 | .22 |
| Male | 2054 (60.8) | 1083 (79.9) | 3.8 (3.13-4.62) | <.001 | <.001 | <.001 |
Abbreviations: AGRE, Autism Genetic Resource Exchange; ASD, autism spectrum disorders; GEE, generalized estimating equations; MDS, multidimensional scaling; NA, not applicable; OR, odds ratio.
a
Generalized estimating equations fit criteria, QIC = 4379.63; QICu = 4379.78.
b
In total, 820 families with 1 to 12 members were analyzed, which encompasses 3376 total individuals of which 1779 were patients with ASD.
c
In the reference haplogroup (HHV+), there were 1356 total individuals of which 630 were patients with ASD.