Table 4. Comparison of the frequencies of solid cancers in the U.S. MCAS patient cohort with the 32-year prevalences of these cancers in the general U.S. population (from Cancer Statistics Review 1975–2013; all races) 41.
| Malignant diseases of the | 32-year prevalence in the U.S.
population |
MCAS patients; n=411 |
|---|---|---|
| Skin: melanoma | f, age 0–39 years: 0.042%
f, age > 39 years: 0.418% m, age 0–49 years: 0.022% m, age >49 years: 0.681% |
(n= 69) 0
(n=218) 1 = 0.46%, ns (n=49) 0 (n=77) 1 = 1.30%, ns |
|
Skin: basal cell and
squamous cell carcinoma |
f, m, all ages: 0.63% 1 | (n=411) 14 [7 BCC] = 1.70% |
| Lung | f, age 0–49 years : 0.009%
f, age > 49 years: 0.422% m, age 0–49 years: 0.005% m, age >49 years: 0.444% |
(n=119)
2 = 1.68%, P<0.0001
(n=168) 3 = 1.19%, ns (n=49) 0 (n=77) 0 |
| Mesothelium | f, m, all ages: 0.001% | (n=411) 1 = 0.24% |
| Stomach | f, age 0–69 years: 0.018%
f, age > 69 years: 0.120% m,age 0–59 years: 0.014% m, age > 59 years: 0.166% |
(n=228) 0
(n=59) 0 (n=73) 0 (n=53) 0 |
| Gut: carcinoma | f,m, age 0–59: 0.10%
f,m, age > 59 years: 1.54% |
(n=251) 0
(n=162) 3 = 1.23%, ns |
| Liver | f,m, age 0–39: 0.002%
f,m, age > 39 years: 0.05% |
(n=94)
(n=319) 1 = 0.31%, ns |
| Breast | 0–39 years: 0.01%
> 39 years: 2.68% |
(n=69) 0
(n=218) 10 = 4.59%, ns |
|
Uterus:
cervix body |
0–39 years: 0.03% > 39 years: 0.17% 0–39 years: 0.03% > 39 years: 0.76% |
(n=69) 0 (n=218) 5 = 2.29%, P<0.0001 (n=69) 0 (n=218) 4 = 1.84%, ns |
| Ovary | 0–39 years: 0.015%
> 39 years: 0.184% |
(n=69)
(n=218) 1 = 0.46%, P=0.0192 |
| Vulva | epidemiological data not available | f 74 ys, f 69 ys |
| Prostate | age 0–59 years: 0.272%
age >59 years: 10.608% |
(n=73) 0
(n=53) 5 = 9.43%, ns |
| Testis | 0–39 years: 0.0.063%
> 39 years: 0.099% |
(n=25) 0
(n=101) 0 |
| Urinary bladder | f, age 0–59 years: 0.011%
f, age > 59 years: 0.344% m, age 0–59 years: 0.037% m, age > 59 years: 1.442% |
(n=178) 0
(n=109) 2 = 1.84%, ns (n=73) 0 (n=53) 3 = 5.66%, P=0.0346 |
| Thyroid gland | f, all ages : 0.215%
m, all ages: 0.062% |
(n=287)
5 = 1.39%, P=0.0057
(n=126) 1 = 0.79%, ns |
| Carcinoid | epidemiological data not available | f 29 ys, f 75ys |
| Sarcoma | epidemiological data not available |
f 61 ys (sarcoma type not
specified) |
Parentheses, number of patients in the respective age group; bold print, number of affected patients; f, female; m, male, ys, years; BCC, basal cell carcinoma. P, two-sided P value in the Chi-square-test; ns, not significant
1Statistics of basal and squamous cell skin cancers are not reported to and tracked by cancer registries. Data based on mathematical modeling are taken from 48.