Table 2. Association of Time to Development of Autonomic Dysfunction (Dependent Variable) With Other Explanatory Variables Using a Linear Regression Model.
| Explanatory Variablea | Regression Coefficient (95% CI) | P Value |
|---|---|---|
| Age at diagnosis | −0.40 (−0.54 to −0.27) | <.001 |
| Male sex (vs female) | −7.13 (−10.06 to −4.20) | <.001 |
| PIGD PD subtype (vs tremor predominant) | −10.08 (−15.16 to −5.00) | <.001 |
| Excellent levodopa treatment response (vs nil to mild) | 12.19 (4.87 to 19.52) | .001 |
| Maximum levodopa equivalent dose | 5.56 (2.14 to 8.98) | .002 |
| Lewy pathologic type | ||
| Limbic (vs brainstem) | 2.27 (−9.42 to 13.96) | .70 |
| Neocortical (vs brainstem) | 2.96 (−8.57 to 14.48) | .61 |
Abbreviations: PD, Parkinson disease; PIGD, postural instability and gait difficulty.
a
The different forms of the main explanatory variables were considered in turn in different linear regression models (not in the same model).