Table 1. Odds Ratio for Prevalent Cardiovascular Disease by Quintiles of mtDNA Copy Number.
| Event | ARIC | CHS | ||||
|---|---|---|---|---|---|---|
| No./Total No. of Events | Model 1, OR (95% CI)a | Model 2, OR (95% CI) | No./Total No. of Events | Model 1, OR (95% CI) | Model 2, OR (95% CI) | |
| Coronary heart disease | ||||||
| Q1 | 236/2231 | 1.97 (1.57-2.48) | 1.66 (1.31-2.11) | 141/966 | 1.92 (1.43-2.59) | 1.80 (1.33-2.45) |
| Q2 | 181/2230 | 1.44 (1.14-1.83) | 1.31 (1.02-1.67) | 122/966 | 1.56 (1.16-2.11) | 1.57 (1.16-2.14) |
| Q3 | 146/2231 | 1.15 (0.89-1.47) | 1.15 (0.89-1.50) | 107/966 | 1.28 (0.95-1.74) | 1.30 (0.95-1.79) |
| Q4 | 149/2230 | 1.16 (0.91-1.49) | 1.23 (0.95-1.59) | 87/966 | 1.06 (0.77-1.45) | 1.03 (0.74-1.43) |
| Q5 | 130/2231 | 1 [Reference] | 1 [Reference] | 85/966 | 1 [Reference] | 1 [Reference] |
| Continuousb | 842/11 153 | 1.26 (1.18-1.35) | 1.18 (1.10-1.26) | 542/4830 | 1.26 (1.15-1.39) | 1.24 (1.12-1.37) |
| P trend | NA | <.001 | <.001 | NA | <.001 | <.001 |
| Stroke | ||||||
| Q1 | 73/2231 | 2.22 (1.48-3.40) | 1.84 (1.22-2.84) | 53/966 | 2.61 (1.59-4.41) | 2.47 (1.50-4.18) |
| Q2 | 44/2230 | 1.31 (0.83-2.07) | 1.17 (0.74-1.86) | 41/966 | 1.91 (1.14-3.27) | 1.89 (1.13-3.25) |
| Q3 | 44/2231 | 1.31 (0.83-2.08) | 1.29 (0.82-2.05) | 39/966 | 1.78 (1.06-3.06) | 1.76 (1.05-3.04) |
| Q4 | 42/2230 | 1.24 (0.79-1.97) | 1.27 (0.80-2.02) | 48/966 | 2.19 (1.33-3.69) | 2.15 (1.30-3.64) |
| Q5 | 34/2231 | 1 [Reference] | 1 [Reference] | 23/966 | 1 [Reference] | 1 [Reference] |
| Continuousb | 237/11 153 | 1.23 (1.09-1.37) | 1.14 (1.01-1.28) | 204/4830 | 1.28 (1.11-1.49) | 1.26 (1.09-1.46) |
| P trend | NA | <.001 | .03 | NA | <.001 | .002 |
| Cardiovascular disease | ||||||
| Q1 | 283/2231 | 2.01 (1.63-2.49) | 1.71 (1.37-2.13) | 188/966 | 2.24 (1.71-2.93) | 2.14 (1.62-2.83) |
| Q2 | 208/2230 | 1.39 (1.12-1.74) | 1.26 (1.00-1.59) | 157/966 | 1.71 (1.30-2.25) | 1.73 (1.31-2.30) |
| Q3 | 178/2231 | 1.18 (0.94-1.48) | 1.19 (0.94-1.51) | 134/966 | 1.36 (1.03-1.80) | 1.37 (1.03-1.83) |
| Q4 | 179/2230 | 1.18 (0.94-1.48) | 1.24 (0.98-1.57) | 122/966 | 1.25 (0.94-1.66) | 1.22 (0.91-1.64) |
| Q5 | 155/2231 | 1 [Reference] | 1 [Reference] | 103/966 | 1 [Reference] | 1 [Reference] |
| Continuousa | 1003/11 153 | 1.26 (1.18-1.33) | 1.17 (1.10-1.25) | 704/4830 | 1.31 (1.21-1.43) | 1.30 (1.19-1.42) |
| P trend | NA | <.001 | <.001 | NA | <.001 | <.001 |
Abbreviations: ARIC, Atherosclerosis Risk in Communities; CHS, Cardiovascular Health Study; mtDNA, mitochondrial DNA; NA, not applicable; OR, odds ratio; Q, quintile.
a
Model 1 is adjusted for age, sex, collection center, and race/ethnicity. Model 2 is model 1 additionally adjusted for total cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, current smoking status, hypertension medication status, and type 2 diabetes status.
b
Continuous OR is per 1-SD decrease in mtDNA copy number.