Table 3. Change in C Statistic for CVD With mtDNA-CN Over Base AHA Risk Score Model in the Pooled Cohorts.

Risk Score	C Statistic (95% CI)
	CHD	Stroke	CVD
AHA Risk Score	0.747 (0.733-0.759)	0.763 (0.747-0.780)	0.752 (0.742-0.761)
AHA Risk Score and mtDNA-CN	0.760 (0.745-0.774)	0.762 (0.745-0.777)	0.759 (0.751-0.769)
Δ C statistic, %	1.2 (0.8-1.6)	−0.2 (−0.5 to 0.2)	0.7 (0.4-1.0)

Abbreviations: AHA, American Heart Association; CHD, coronary heart disease; CVD, cardiovascular disease; mtDNA-CN, mitochondrial DNA copy number.