Figure 2. Serial Changes in the 16-Item Quick Inventory of Depressive Symptomatology–Clinician Rated (QIDS-C₁₆) Scores.

Participants completed at least 1 assessment after randomization and were included in the primary analysis. Error bars indicate SDs, which were calculated separately for each time point. Each of the 16 QIDS-C₁₆ items can yield a score of 0 to 3 on a Likert scale. The score range is 0 to 27; higher scores indicate more severe depression; a score of 0 to 5 corresponds to a normal affect; 6 to 10 to a mild affect; 11 to 15 to a moderate affect; 16 to 20 to a severe affect; and 21 or greater to very severe depression.