Figure 3. Case 3: Chromosomal Copy Number Variation Profile Showing Similar Chromosomal Gains and Losses Over Time in a Patient Treated With Multiple Intravitreous Injections of Melphalan With Concurrent Aqueous Humor (AH) Extraction During Each Injection.

A-D, Chromosomal copy number variation profile from cell-free DNA in the AH from sequential samples (AH 1 through AH 4). E, Chromosomal copy number variation profile from tumor after subsequent (secondary) enucleation showing that the same chromosomal changes seen initially in the AH were also found in the tumor. F, Overlay of the AH and tumor chromosomal copy number variation profiles (AH is blue, and tumor is red).