Table 3. RCM Lip Scorea for Diagnosis.
| RCM Featureb | Pointsc | Interrater Agreement κ Coefficient (95% CI) |
|---|---|---|
| Regular honeycombed pattern | -1 | 0.69 (0.31-1.08) |
| Epidermal disarray, disarranged pattern | +1 | 0.9 (0.71-1.09) |
| Presence of dendritic or roundish pagetoid cells | +2 | 0.91 (0.74-1.08) |
| Homogeneous distributed papilllae | −1 | 0.81 (0.55-1.06) |
| Dishomogeneous distributed papillae | +1 | 0.64 (0.32-0.95) |
| Marked cellular atypia at the DEJa | +1 | 1 |
| Interpapillar distribution of atypical cells in relationship with the papillae | +1 | 0.91 (0.74-1.08) |
Abbreviations: DEJ, dermoepidermal junction; RCM, reflectance confocal microscopy.
a
An RCM score is calculated adding every positive and negative RCM feature.
b
An RCM feature is defined as: numerous cells irregular in size, shape, and reflectivity, round to oval or stellate, occasionally with branching dendriticlike structures, and/or distributed throughout the lesion.
c
An RCM score of 4 or greater corresponded to the threshold for the diagnosis of melanoma.