Figure 2. Comparison of Trials Including Patients With Coronary Artery Disease (CAD) Involving Left Main Coronary Artery (LMCA) Stenosis vs Trials Including Patients With Multivessel CAD (MV-CAD) Without LMCA Involvement.

The group of trials of patients with CAD involving the LMCA differed significantly from the group with MV-CAD without LMCA involvement. BEST indicates Bypass Surgery vs Everolimus-Eluting Stent Implantation for Multivessel Coronary Artery Disease; CABG, coronary artery bypass grafting; EXCEL, Evaluation of Xience vs Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization (Xience; Abbott Vascular); FREEDOM, Future Revascularization Evaluation in Patients with Diabetes Mellitus; HR, hazard ratio; NOBLE, Nordic-Baltic-British Left Main Revascularisation; PCI, percutaneous coronary intervention; and SYNTAX, Synergy Between PCI With Taxus and Cardiac Surgery (Taxus; Boston Scientific).

^aTesting for interaction by using values for fixed-effect and random-effects models, respectively.