Table 2. Diagnostic Performance of CCTA, SPECT, PET, and Hybrid Cardiac Imaging for Diagnosis of Ischemia-Causing Coronary Artery Disease as Indicated by Fractional Flow Reserve .
| Characteristic | % (95% CI) | ||||
|---|---|---|---|---|---|
| CCTA | SPECT | PET | Hybrid SPECT and CCTA |
Hybrid PET and CCTA |
|
| Per patient | |||||
| Sensitivity | 90 (82-95) | 57 (46-67) | 87 (78-93) | 50 (39-61) | 74 (64-83) |
| Specificity | 60 (51-69) | 94 (88-98) | 84 (75-89) | 97 (93-99) | 92 (86-96) |
| PPV | 64 (55-73) | 88 (77-95) | 81 (72-89) | 94 (83-99) | 88 (79-94) |
| NPV | 89 (80-95) | 73 (65-80) | 89 (81-94) | 71 (63-78) | 82 (74-88) |
| Accuracy | 74 (67-79) | 77 (71-83) | 85 (80-90) | 76 (70-82) | 84 (79-89) |
| Per vessel | |||||
| Sensitivity | 72 (64-79) | 39 (32-48) | 81 (73-87) | 35 (27-43) | 64 (55-71) |
| Specificity | 78 (74-82) | 96 (94-98) | 75 (69-81) | 99 (98-100) | 97 (95-98) |
| PPV | 52 (44-59) | 80 (70-87) | 59 (51-66) | 87 (65-96) | 87 (79-92) |
| NPV | 87 (83-91) | 81 (76-85) | 92 (88-95) | 81 (76-85) | 88 (84-91) |
| Accuracy | 77 (73-80) | 82 (78-85) | 79 (75-83) | 83 (79-86) | 88 (85-91) |
Abbreviations: CCTA, coronary computed tomography angiography; NPV, negative predictive value; PET, positron emission tomography; PPV, positive predictive value; SPECT, single-photon emission computed tomography.