Table 1. Baseline Characteristics and DDAF and Total Area of the Lesions (DDAF + QDAF).
| Characteristic | First Visit With DDAF Present (224 Eyes) | DDAF + QDAF (386 Eyes) | ||||
|---|---|---|---|---|---|---|
| No. | DDAF Area, Mean (SD), mm2 |
P Value | No. | Total Area, Mean (SD), mm2 |
P Value | |
| Demographics | ||||||
| Age at first visit, y | ||||||
| <18 | 38 | 1.8 (1.8) | .02a | 93 | 2.2 (2.6) | .009a |
| 18-29 | 67 | 1.6 (1.6) | 123 | 2.0 (2.1) | ||
| ≥30 | 119 | 2.6 (3.3) | 170 | 3.1 (3.1) | ||
| Age at onset of symptoms, y | ||||||
| <18 | 89 | 2.3 (2.8) | .72b | 162 | 2.6 (2.8) | .44b |
| 18-29 | 50 | 1.8(2.2) | 85 | 2.4 (2.2) | ||
| ≥30 | 51 | 2.7 (3.4) | 81 | 3.0 (3.4) | ||
| Unknown | 34 | 1.7 (1.9) | 58 | 2.3 (2.4) | ||
| Duration, y | ||||||
| <10 | 103 | 1.6 (2.2) | .004 | 230 | 2.1 (2.6) | <.001 |
| ≥10 | 87 | 3.0 (3.2) | 98 | 3.1 (2.9) | ||
| Unknown | 34 | 1.7 (1.9) | 58 | 2.3 (2.4) | ||
| Sex | ||||||
| Male | 101 | 2.6 (2.9) | .12 | 160 | 2.8 (2.7) | .29 |
| Female | 123 | 1.9 (2.4) | 226 | 2.4 (2.8) | ||
| Qualitative FAF Grading Parameters | ||||||
| Flecks | ||||||
| Absent | 6 | 3.2 (1.6) | .24 | 57 | 1.2 (1.1) | <.001 |
| Present | 214 | 2.2 (2.7) | 329 | 2.8 (2.9) | ||
| Questionable | 4 | 1.1 (0.9) | 0 | NA | ||
| Flecks beyond the arcades | ||||||
| Absent | 72 | 1.4 (1.5) | .001 | 195 | 1.5 (1.7) | <.001 |
| Present | 151 | 2.6 (3.0) | 186 | 3.7 (3.2) | ||
| Questionable | 1 | 0.6c | 0 | NA | ||
| Cannot grade | 0 | NA | 5 | 0.9 (1.7) | ||
| Increased FAF at DDAF lesion edge | ||||||
| Absent | 122 | 2.2 (2.8) | .75 | 189 | 2.8 (2.8) | .46 |
| Present | 80 | 1.9 (2.3) | 157 | 2.3 (2.7) | ||
| Questionable | 22 | 2.9 (3.4) | 39 | 2.7 (2.7) | ||
| Background | ||||||
| Homogeneous | 121 | 1.5 (2.1) | .001 | 259 | 1.9 (2.0) | <.001 |
| Heterogeneous | 103 | 2.9 (3.1) | 127 | 4.0 (3.4) | ||
| No. of lesions of DDAF | ||||||
| Unifocal | 161 | 2.0 (2.5) | .25 | 131 | 3.9 (3.1) | <.001 |
| Multifocal | 63 | 2.6 (2.9) | 54 | 3.9 (3.7) | ||
| NA | 0 | NA | 201 | 1.4 (1.4) | ||
| Background signal and flecks beyond the arcades | ||||||
| Homogeneous with no flecks beyond the arcades | 72 | 1.4 (1.5) | <.001b | 195 | 1.5 (1.7) | <.001b |
| Homogeneous with flecks beyond the arcades | 48 | 1.8 (2.7) | 60 | 3.0 (2.6) | ||
| Heterogeneousd | 103 | 2.9 (3.1) | 127 | 4.0 (3.4) | ||
| Cannot grade flecks | 1 | 0.6c | 4 | 1.0 (1.0) | ||
| Overall | 224 | 2.2 (2.7) | NA | 386 | 2.6 (2.8) | NA |
Abbreviations: DDAF, definitely decreased autofluorescence; FAF, fundus autofluorescence; NA, not applicable; QDAF, questionably decreased autofluorescence.
a
Using age at first visit.
b
Test for trend and categories not included in the statistical testing, accounting for within-eye correlation.
c
No SD provided because the value is from only 1 eye.
d
All images graded as heterogeneous background were graded as having flecks beyond the arcades.