Table. Lithium Exposure and Rates of Dementia (Overall), Alzheimer Disease, and Vascular Dementia.
| Mean Lithium Exposure, µg/L | No. (%) | Incidence Rate Ratio (95% CI) | P Value | |
|---|---|---|---|---|
| Patients | Control Individuals | |||
| Dementia (Overall) | ||||
| 2.0-5.0 | 9105 (12.4) | 90 052 (12.4) | 1 [Reference] | |
| 5.1-10.0 | 19 694 (26.9) | 158 627 (21.8) | 1.22 (1.19-1.25) | <.001 |
| 10.1-15.0 | 26 471 (36.1) | 264 647 (36.3) | 0.98 (0.96-1.01) | .17 |
| 15.1-27.0 | 18 010 (24.6) | 214 947 (29.5) | 0.83 (0.81-0.85) | <.001 |
| Alzheimer Disease | ||||
| 2.0-5.0 | 3700 (12.7) | 35 485 (12.3) | 1 [Reference] | |
| 5.1-10.0 | 7974 (27.5) | 62 832 (21.8) | 1.22 (1.17-1.27) | <.001 |
| 10.1-15.0 | 10 457 (36.0) | 105 251 (36.5) | 0.95 (0.92-1.00) | .02 |
| 15.1-27.0 | 6896 (23.8) | 85 115 (29.5) | 0.78 (0.74-0.81) | <.001 |
| Vascular Dementia | ||||
| 2.0-5.0 | 1827 (12.4) | 18 328 (12.5) | 1 [Reference] | |
| 5.1-10.0 | 4019 (27.3) | 31 994 (21.9) | 1.26 (1.19-1.33) | <.001 |
| 10.1-15.0 | 5129 (34.9) | 52 788 (36.1) | 0.97 (0.92-1.03) | .34 |
| 15.1-27.0 | 3736 (25.4) | 43 181 (29.5) | 0.87 (0.81-0.91) | <.001 |