Table 1. General Characteristics of the Study Groups.
| Characteristic | No. (%) | |
|---|---|---|
| Noncarriers (n = 102; 204 Eyes) |
Carriers (n = 51; 100 Eyes) |
|
| Age at participation, mean (SD), y | 67.1 (11.8) | 66.7 (12.1) |
| Sex | ||
| Male | 46 (45.1) | 18 (35.3) |
| Female | 56 (54.9) | 33 (64.7) |
| Smoking status | ||
| Never | 21 (22.3) | 16 (39.0) |
| Past | 53 (56.4) | 17 (41.5) |
| Current | 20 (21.3) | 8 (19.5) |
| BMI, mean (SD) | 26.1 (4.1) | 26.5 (4.2) |
| Family history for AMD | ||
| Yes | 52 (58.4) | 27 (67.5) |
| No | 37 (41.6) | 13 (32.5) |
| Common genetic variants, No. of minor alleles/total No. of alleles (MAF %) | ||
| ARMS2, rs10490923, T | 75/176 (42.6) | 17/74 (23.0) |
| CFH, rs1061170, C | 99/176 (56.3) | 29/76 (38.2) |
| C3, rs2230199, G | 49/174 (28.2) | 29/76 (38.2) |
Abbreviations: AMD, age-related macular degeneration; ARMS2, age-related maculopathy susceptibility 2; BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); CFH, complement factor H; C3, complement component 3; MAF, minor allele frequency.