Table 2. Factors Associated With Survival Among 6365 Patients With Early-Stage Colon Cancer Resected in Ontario, Canada, Between 2002 and 2008.
| Covariate | 5-y Overall Survival | 5-y Cancer-Specific Survival | ||||
|---|---|---|---|---|---|---|
| No./Total No. (%) | Multivariable Analysis | No./Total No. (%) | Multivariable Analysis | |||
| HR (95% CI) | P for Trend | HR (95% CI) | P for Trend | |||
| Age group, y | ||||||
| <60 | 887/1201 (73.9) | 1 [Reference] | <.001 | 911/1201 (75.9) | 1 [Reference] | <.001 |
| 60-69 | 1057/1518 (69.6) | 1.15 (1.01-1.32) | 1108/1518 (73.0) | 1.11 (0.95-1.30) | ||
| 70-79 | 1299/2127 (61.1) | 1.59 (1.40-1.80) | 1465/2127 (68.9) | 1.33 (1.15-1.53) | ||
| ≥80 | 687/1519 (45.2) | 2.45 (2.15-2.80) | 948/1519 (62.4) | 1.58 (1.35-1.86) | ||
| Sex | ||||||
| Male | 1965/3267 (60.2) | 1 [Reference] | <.001 | 2227/3267 (68.2) | 1 [Reference] | <.001 |
| Female | 1965/3098 (63.4) | 0.79 (0.73-0.85) | 2213/3098 (71.4) | 0.80 (0.73-0.89) | ||
| Socioeconomic status quintilea | ||||||
| 1 | 781/1345 (58.1) | 1.11 (0.98-1.26) | .03 | 901/1345 (67.0) | 1.11 (0.95-1.30) | .18 |
| 2 | 875/1501 (58.3) | 1.15 (1.02-1.31) | 1019/1501 (67.9) | 1.17 (1.00-1.37) | ||
| 3 | 873/1376 (63.4) | 0.99 (0.87-1.13) | 987/1376 (71.8) | 1.01 (0.86-1.18) | ||
| 4 | 750/1153 (65.1) | 1.01 (0.89-1.16) | 823/1153 (71.4) | 1.07 (0.90-1.26) | ||
| 5 | 635/971 (65.4) | 1 [Reference] | 693/971 (71.3) | 1 [Reference] | ||
| Charlson Comorbidity Indexb | ||||||
| 0 | 3276/4987 (65.7) | 1 [Reference] | <.001 | 3545/4987 (71.1) | 1 [Reference] | .003 |
| ≥1 | 655/1378 (47.5) | 1.59 (1.46-1.73) | 887/1378 (64.3) | 1.19 (1.06-1.33) | ||
| Lymphovascular invasion | ||||||
| No | 2856/4107 (69.5) | 1 [Reference] | <.001 | 3231/4107 (78.7) | 1 [Reference] | <.001 |
| Yes | 788/1769 (44.6) | 1.57 (1.44-1.71) | 882/1769 (49.9) | 1.77 (1.59-1.97) | ||
| Unstated | 287/489 (58.6) | 1.37 (1.19-1.57) | 329/489 (67.2) | 1.54 (1.29-1.83) | ||
| Stage | ||||||
| I | 935/1163 (80.4) | 1 [Reference] | <.001 | 1063/1163 (91.4) | 1 [Reference] | <.001 |
| II | 1705/2446 (69.7) | 1.51 (1.32-1.72) | 1941/2446 (79.4) | 2.32 (1.87-2.88) | ||
| III | 1291/2756 (46.8) | 3.33 (2.89-3.83) | 1438/2756 (52.2) | 6.69 (5.37-8.34) | ||
| Adjuvant chemotherapy | ||||||
| Yes | 1361/2212 (61.5) | 0.61 (0.55-0.68) | <.001 | 1432/2212 (64.7) | 0.58 (0.52-0.66) | <.001 |
| No | 2570/4153 (61.9) | 1 [Reference] | 3019/4153 (72.7) | 1 [Reference] | ||
| Gradec | ||||||
| Well to moderately differentiated | 3367/5253 (64.1) | 1 [Reference] | <.001 | 3819/5253 (72.7) | 1 [Reference] | <.001 |
| Poorly differentiated | 476/990 (48.0) | 1.28 (1.16-1.41) | 525/990 (53.1) | 1.46 (1.30-1.63) | ||
| Laterality | ||||||
| Right | 1976/3291 (60.0) | 1.00 (0.92-1.08) | .96 | 2263/3291 (68.8) | 1.00 (0.91-1.10) | .96 |
| Left | 1955/3074 (63.6) | 1 [Reference] | 2178/3074 (70.9) | 1 [Reference] | ||
Abbreviation: HR, hazard ratio.
a
Socioeconomic status quintile 1 represents the lowest socioeconomic status. Socioeconomic data were not available for 19 patients.
b
Charlson Comorbidity Index does not include age and colon cancer.
c
Grade unstated for 122 patients.