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. 2017 Aug 10;58(6):827–833. doi: 10.1093/jrr/rrx041

Fig. 2.

Fig. 2.

WBI activated the NMDAR/NFAT3/c4/Bax pathway and induced apoptosis. WBI significantly elevated the expression of: NMDAR subunits (NR2A, not NR1 or NR2B) (A), NFAT3/c4 in the nucleus (C), the apoptosis marker Bax (D) compared with in the sham group. In contrast, the expression of CaN and GSK-3β showed only mild enhancement compared with in the sham group (B). Data are expressed as mean ± SD, *P < 0.05 vs sham group, #P < 0.05 vs irradiation group.