Table 2. TSPO Density Measured By VT Across Multiple Brain Regions in Obsessive-Compulsive Disorder.
| Region of Interest | TSPO VT, Mean (SD)a | Difference, % | Effect | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Obsessive-Compulsive Disorder | Healthy | Diagnosis | Genotype | ||||||||
| HAB (n = 13) |
MAB (n = 7) |
Total (n = 20) |
HAB (n = 13) |
MAB (n = 7) |
Total (n = 20) |
F1,37 | P Value | F1,37 | P Value | ||
| Dorsal caudate | 10.7 (2.3) | 6.9 (1.4) | 9.4 (2.7) | 7.8 (2.1) | 5.2 (1.7) | 6.9 (2.3) | 35.6 | 15.5 | <.001 | 23.9 | <.001 |
| OFC | 13.4 (2.8) | 9.3 (2.1) | 12.0 (3.2) | 10.1 (2.5) | 7.5 (2.0) | 9.2 (2.6) | 30.9 | 13.5 | .001 | 17.5 | <.001 |
| Thalamus | 16.2 (3.2) | 8.9 (2.4) | 13.7 (4.6) | 11.3 (3.0) | 8.3 (2.0) | 10.2 (3.0) | 33.5 | 13.2 | .001 | 26.5 | <.001 |
| Ventral striatum | 12.1 (2.2) | 6.8 (1.3) | 10.2 (3.2) | 8.3 (2.1) | 6.4 (1.8) | 7.6 (2.2) | 33.8 | 14.4 | .001 | 25.6 | <.001 |
| Dorsal putamen | 11.8 (2.4) | 6.6 (1.7) | 10.0 (3.3) | 8.3 (2.1) | 6.1 (1.5) | 7.5 (2.1) | 32.6 | 12.8 | .001 | 26.2 | <.001 |
| ACC | 12.4 (2.3) | 6.9 (1.7) | 10.5 (3.4) | 9.5 (2.0) | 6.5 (1.4) | 8.5 (2.3) | 23.5 | 9.5 | .004 | 40.3 | <.001 |
| MPFC | 12.8 (2.4) | 7.1 (1.7) | 10.8 (3.5) | 9.4 (2.1) | 6.7 (1.3) | 8.4 (2.2) | 27.5 | 11.9 | .001 | 34.8 | <.001 |
| DLPFC | 13.0 (2.1) | 7.3 (1.9) | 11.0 (3.4) | 10.0 (2.0) | 7.1 (1.8) | 9.0 (2.3) | 22.0 | 9.1 | .005 | 38.5 | <.001 |
| VLPFC | 13.9 (2.6) | 8.2 (1.8) | 11.9 (3.6) | 10.7 (2.2) | 7.7 (2.0) | 9.6 (2.5) | 23.9 | 10.0 | .003 | 31.8 | <.001 |
| Insula | 13.3 (2.6) | 7.5 (1.8) | 11.3 (3.6) | 9.9 (2.3) | 6.9 (1.5) | 8.8 (2.5) | 27.7 | 11.4 | .002 | 33.0 | <.001 |
| Temporal cortex | 13.5 (2.5) | 7.8 (2.1) | 11.5 (3.6) | 10.4 (2.3) | 7.2 (1.8) | 9.3 (2.6) | 24.3 | 9.5 | .004 | 33.5 | <.001 |
| Inferior parietal cortex | 14.1 (3.1) | 8.1 (1.8) | 12.0 (4.0) | 10.9 (2.2) | 7.9 (1.9) | 9.8 (2.6) | 22.2 | 7.5 | .009 | 29.8 | <.001 |
| Occipital cortex | 13.9 (2.6) | 7.8 (2.1) | 11.8 (3.8) | 10.6 (2.4) | 7.4 (1.9) | 9.5 (2.7) | 23.8 | 8.9 | .005 | 33.9 | <.001 |
| Hippocampus | 12.2 (2.3) | 6.9 (2.0) | 10.3 (3.3) | 8.7 (2.5) | 6.8 (2.0) | 8.0 (2.5) | 28.9 | 9.4 | .004 | 20.3 | <.001 |
Abbreviations: ACC, anterior cingulate cortex; ANOVA, analysis of variance; DLPFC, dorsolateral prefrontal cortex; HAB, high-affinity binding; MAB, mixed-affinity binding; MPFC, medial prefrontal cortex; OFC, orbitofrontal cortex; TSPO, translocator protein; VLPFC, ventrolateral prefrontal cortex; VT, distribution volume.
a
Indicates binding to the single-nucleotide polymorphism rs6971 of the TSPO gene known to influence binding of second-generation TSPO radioligands, including fluorine F 18–labeled N-(2-(2-fluoroethoxy)benzyl)-N-(4-phenoxypyridin-3-yl)acetamide.