Table 3. Biomarker Summary Statistics Across All Visits.
| Biomarker | Minimum | Median (IQR) | Mean (SD) | Maximum |
|---|---|---|---|---|
| EBC MDA, µM | 1.6 | 20.4 (13.5) | 22.4 (14.0) | 118.6 |
| FeNO, ppb | 1.1 | 6.0 (5.0) | 7.2 (4.5) | 34.8 |
| EBCNN, ng/mL | 301.0 | 1409.7 (1811.8) | 2910.7 (4935.1) | 46657.2 |
| FEV1, L | 1.9 | 3.2 (0.7) | 3.2 (0.5) | 4.6 |
| FVC, L | 2.3 | 3.9 (1.0) | 3.9 (0.7) | 5.9 |
| FEV1:FVC, % | 59.7 | 81.9 (7.1) | 82.0 (6.2) | 98.3 |
| 8-OHdG, ng/mLa | 0.5 | 4.0 (3.7) | 4.4 (2.3) | 14.4 |
| SBP, mm Hg | 90 | 111 (13.0) | 112.3 (10.8) | 159 |
| DBP, mm Hg | 51 | 63 (8.0) | 64.6 (7.0) | 89 |
| AI, % | 0 | 15.3 (9.3) | 16.0 (6.7) | 40.0 |
| PWV, m/s | 4.3 | 6.3 (1.2) | 6.4 (1.1) | 14.3 |
| CRP, ng/mL | 12.5 | 260.5 (450.4) | 870.9 (2035.4) | 18764.2 |
| sCD62P, ng/mL | 10.9 | 22.9 (9.3) | 24.3 (7.5) | 60.4 |
| VWF, µg/mL | 3.5 | 30.1 (20.5) | 32.3 (15.7) | 82.8 |
Abbreviations: 8-OHdG, urinary 8-hydroxy-2′-deoxyguanosine; AI, augmentation index; CRP, C-reactive protein; DBP, diastolic blood pressure; EBC MDA exhaled breath condensate malondialdehyde; EBCNN, EBC nitrite and nitrate; FeNO, fractional exhaled nitric oxide; FEV1, forced expiratory volume in the first second; FVC, forced vital capacity; ppb, parts per billion; PWV, pulse wave velocity; SBP, systolic blood pressure; sCD62P, soluble P-selectin; VWF, von Willebrand factor.
SI conversion factor: To convert CRP to nanomoles per liter, multiply by 0.0095.
a
Concentrations of 8-OHdG are adjusted by specific gravity.