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. 2017 Aug 16;2(8):863–870. doi: 10.1001/jamacardio.2017.1855

Table 2. Relative Risk of and Tetrachoric Correlation for AF in First-Degree Relatives.

Sex of Affected Relative Sex of Individual No. of Cases Prevalence, %a Relative Risk (95% CI)b Tetrachoric Correlation (95% CI)b
Any Relative
Male Male 1248 1.2 2.20 (2.06-2.35) 0.10 (0.09-0.10)
Female 701 0.9 2.01 (1.87-2.16) 0.11 (0.10-0.11)
All 1949 1.1 2.20 (2.09-2.31) 0.10 (0.10-0.11)
Female Male 1352 1.7 1.79 (1.70-1.88) 0.18 (0.18-0.19)
Female 335 0.7 1.59 (1.40-1.81) 0.11 (0.10-0.11)
All 1687 1.4 1.79 (1.71-1.88) 0.17 (0.16-0.17)
All Male 2493 1.4 1.93 (1.85-2.01) 0.11 (0.11-0.12)
Female 1016 0.8 1.84 (1.73-1.96) 0.08 (0.07-0.08)
All 3509 1.2 1.96 (1.88-2.04) 0.10 (0.10-0.11)
Parent
Male Male 784 0.8 2.03 (1.89-2.17) 0.30 (0.29-0.31)
Female 139 0.2 1.43 (1.21-1.69) 0.22 (0.20-0.23)
All 923 0.6 1.98 (1.86-2.11) 0.29 (0.28-0.29)
Female Male 1264 1.7 1.78 (1.69-1.88) 0.36 (0.35-0.37)
Female 224 0.5 1.46 (1.28-1.66) 0.31 (0.30-0.33)
All 1488 1.3 1.77 (1.69-1.86) 0.36 (0.35-0.36)
All Male 1973 1.2 1.83 (1.76-1.91) 0.32 (0.32-0.33)
Female 349 0.3 1.42 (1.28-1.58) 0.26 (0.25-0.27)
All 2322 0.8 1.81 (1.74-1.89) 0.32 (0.31-0.32)
Offspring
Male Male 362 12.2 2.72 (2.47-2.99) 0.33 (0.32-0.34)
Female 535 9.8 2.28 (2.11-2.47) 0.36 (0.35-0.37)
All 897 10.7 2.50 (2.35-2.65) 0.34 (0.33-0.35)
Female Male 65 6.5 1.84 (1.47-2.32) 0.20 (0.18-0.23)
Female 105 6.6 1.92 (1.60-2.30) 0.29 (0.27-0.31)
All 170 6.6 1.93 (1.67-2.23) 0.25 (0.23-0.26)
All Male 426 10.8 2.53 (2.32-2.77) 0.31 (0.30-0.31)
Female 639 9.1 2.22 (2.06-2.38) 0.35 (0.34-0.35)
All 1065 9.7 2.39 (2.26-2.52) 0.32 (0.32-0.33)
Full Sibling
Male Male 121 2.6 2.45 (1.97-3.04) 0.36 (0.34-0.38)
Female 31 0.9 1.68 (1.19-2.38) 0.32 (0.29-0.35)
All 152 1.8 2.27 (1.88-2.74) 0.35 (0.34-0.37)
Female Male 26 1.6 1.91 (1.31-2.79) 0.33 (0.30-0.36)
Female 9 0.7 3.14 (1.37-7.19) 0.25 (0.25-0.06)
All 35 1.2 2.13 (1.49-3.03) 0.31 (0.29-0.34)
All Male 147 2.3 2.34 (1.93-2.83) 0.36 (0.34-0.37)
Female 40 0.8 1.88 (1.36-2.61) 0.31 (0.29-0.34)
All 187 1.7 2.25 (1.88-2.68) 0.35 (0.33-0.36)
Twin
Male Male 4 16.7 17.37 (3.9-77.40) 0.71 (0.63-0.80)
Female 0 0 NA NA
All 4 13.3 14.78 (3.38-64.71) 0.70 (0.62-0.79)
Female Male 0 NA NA NA
Female 0 NA NA NA
All 0 NA NA NA
All Male 4 14.3 14.14 (3.36-59.51) 0.70 (0.61-0.78)
Female 0 NA NA NA
All 4 9.1 12.15 (2.94-50.21) 0.65 (0.57-0.73)
Spouse
Female Male 1311 5.4 1.18 (1.12-1.24) 0.25 (0.24-0.25)
Male Female 1819 2.8 1.14 (1.09-1.19) 0.23 (0.22-0.23)
All All 3130 3.5 1.15 (1.10-1.20) 0.22 (0.21-0.22)

Abbreviations: AF, atrial fibrillation; NA, not applicable (because of no AF cases with affected twin).

a

Prevalence was equal to recurrence risk.

b

Adjusted for age, sex, occupation, income level, urbanization of residence, and family size.