Table. Three Years’ Outcomes in Women With and Without Acute Myocardial Infarction Treated With New- vs Early-Generation DESa.
| Outcome | Early-Generation DES | New-Generation DES | ARD, % | Adjusted HR (95% CI)b | P Value Interaction | ||
|---|---|---|---|---|---|---|---|
| No. of Events | Kaplan-Meier Estimate, % (95% CI) | No. of Events | Kaplan-Meier Estimate, % (95% CI) | ||||
| Death, Myocardial Infarction, or Target Lesion Revascularization | |||||||
| Unstable angina | 119 | 15.1 (12.8-17.8) | 168 | 14.6 (12.7-16.9) | −0.5 | 0.87 (0.67-1.11) | .59 |
| Acute myocardial infarction | 129 | 18.1 (15.4-21.3) | 168 | 14.6 (12.4-17.1) | −3.5 | 0.78 (0.61-0.99) | |
| Death | |||||||
| Unstable angina | 38 | 5.0 (3.6-6.8) | 56 | 5.5 (4.2-7.2) | 0.5 | 0.99 (0.64-1.54) | .63 |
| Acute myocardial infarction | 64 | 9.0 (7.1-11.4) | 84 | 7.9 (6.2-10.0) | −1.1 | 0.79 (0.56-1.12) | |
| Myocardial Infarction | |||||||
| Unstable angina | 44 | 5.6 (4.1-7.4) | 57 | 4.5 (3.5-5.8) | −1.1 | 0.79 (0.53-1.19) | .86 |
| Acute myocardial infarction | 49 | 7.1 (5.4-9.4) | 64 | 5.1 (3.9-6.6) | −2.0 | 0.76 (0.52-1.12) | |
| Target Lesion Revascularization | |||||||
| Unstable angina | 64 | 8.3 (6.6-10.5) | 77 | 6.6 (5.3-8.3) | −1.7 | 0.70 (0.49-1.01) | .91 |
| Acute myocardial infarction | 47 | 7.1 (5.4-9.5) | 52 | 4.8 (3.6-6.5) | −2.3 | 0.70 (0.46-1.05) | |
| Cardiac Death | |||||||
| Unstable angina | 27 | 3.6 (2.5-5.3) | 23 | 2.1 (1.4-3.2) | −1.5 | 0.57 (0.32-1.02) | .32 |
| Acute myocardial infarction | 42 | 5.9 (4.3-7.9) | 57 | 5.1 (3.8-6.8) | −0.8 | 0.75 (0.49-1.14) | |
| Death, Myocardial Infarction, or Stent Thrombosis | |||||||
| Unstable angina | 77 | 9.8 (7.9-12.1) | 107 | 9.4 (7.8-11.4) | −0.4 | 0.90 (0.66-1.22) | .64 |
| Acute myocardial infarction | 105 | 14.7 (12.3-17.6) | 139 | 11.8 (9.9-14.1) | −2.9 | 0.79 (0.60-1.02) | |
| Definite or Probable Stent Thrombosis | |||||||
| Unstable angina | 12 | 1.6 (0.9-2.8) | 14 | 1.1 (0.7-1.9) | −0.5 | 0.71 (0.30-1.67) | .31 |
| Acute myocardial infarction | 27 | 4.0 (2.7-5.8) | 18 | 1.4 (0.9-2.2) | −2.6 | 0.36 (0.19-0.69) | |
Abbreviations: ARD, absolute risk difference; DES, drug-eluting stents; HR, hazard ratio.
a
This study included 2197 women with unstable angina and 2176 women with acute myocardial infarction.
b
Adjusted HRs are generated with Cox regression analysis including trial identifier as a random effect.