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. 2017 Aug 16;2(8):872–881. doi: 10.1001/jamacardio.2017.1883

Table 2. Number of Events and Crude and Weighted Event Rates According to Treatmenta.

Apixaban Dabigatran Rivaroxaban Warfarin
Events Rate Events Rate Events Rate Events Rate
Crude Weighted Crude Weighted Crude Weighted Crude Weighted
1-y Follow-up
Ischemic stroke/SE 10 0.68 0.83 22 0.70 0.65 14 1.09 1.20 57 0.79 0.81
All-cause death 19 1.62 1.52 51 1.62 1.84 26 2.01 1.67 249 3.45 3.11
Any bleeding 8 0.68 0.57 23 0.74 0.73 17 1.33 1.38 109 1.52 1.53
Intracranial/gastrointestinal bleeding <5 0.09 0.06 6 0.19 0.16 <5 0.23 0.29 39 0.54 0.54
2.5-y Follow-up
Ischemic stroke/SE 14 0.85 0.85 41 0.61 0.58 16 0.75 0.81 109 0.70 0.69
All-cause death 22 1.32 1.21 91 1.33 1.48 49 2.28 2.10 428 2.71 2.47
Any bleeding 11 0.67 0.56 44 0.65 0.65 22 1.04 1.09 202 1.30 1.31
Intracranial/gastrointestinal bleeding <5 0.12 0.12 17 0.25 0.21 6 0.28 0.30 72 0.46 0.45

Abbreviations: IPTW, inverse probability of treatment weighed; SE, systemic embolism.

a

Crude rates are events divided by person time per 100 years; weighted rates are based on IPTW population and express population mean treatment rates per 100 years. Main analysis.