Fig. 6.

Schematic illustration showing some G_i protein and β-arrestin-mediated signaling resulting from PAM binding to CB₁ and subsequent G_i protein and β-arrestin recruitment. G_i protein (orange) binding to CB₁ results in cellular responses such as phosphorylation of ERK1/2, MEK, or JNK1/2 (A). β-Arrestin (green) binding to CB₁, on the other hand, can typically result in the cellular responses including phosphorylation of ERK1/2, MEK, or Src (B). The proteins that are shown here can either be phosphorylated as a result of G_i protein-mediated signaling (brown), β-arrestin-mediated signaling (blue), or both (purple).