Skip to main content
. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Neurobiol Dis. 2017 Oct 16;109(Pt A):137–147. doi: 10.1016/j.nbd.2017.10.011

Figure 6.

Figure 6

Contributions to [Cl−]i from GABAA, and KCC2 activity modulate seizure threshold, duration and onset. A, Seizure threshold as a function of GABAA contribution to [Cl−]i. B, Seizure threshold as a function of KCC2 strength. C, Seizure duration as a function of GABAA contribution to [Cl−]i. D, Seizure duration as a function of KCC2 activity. E, Seizure onset delay as a function of KCC2 activity. Delay was measured between the onset time of a seizure in the control network with 100% KCC2 strength as compared to the seizure onset time in the networks with varied KCC2 strength. Inset shows examples of the filtered seizure LFPs. Colored data points correspond to the sampled data in the inset. Black trace in inset represents the control network with 100% KCC2 activity. Dash line shows threshold used to calculate seizure onset times. F, Examples of different seizure durations as a result of varied KCC2 strength. Top, filtered network LFP. Middle and Bottom, corresponding mean [Cl−]i and [K+]o respectively. Arrows point to the corresponding data points in D.