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. 2017 Oct 10;8(53):90662–90673. doi: 10.18632/oncotarget.21730

Figure 5. CDK1 inhibition resulted in increased sensitivity to multiple genotoxic agents.

Figure 5

A. Synergistic effects between aphidicolin (Aph) and CDK1 inhibitors. Clonogenic assays using U2OS cells treated with increasing concentrations of Aph in the absence or presence of 1 µM CDK1i were conducted. Colony numbers in each group (DMSO or CDKi) were scored as surviving fraction relative to cells without Aph treatment. B.-C. CDK1 inhibition increased the sensitivity of U2OS cells to clinically-used chemotherapeutic drugs including cisplatin B. and the PARP inhibitor, Olaparib C.. Cells were analyzed as indicated in A. D. A549 cells were treated with increasing concentrations of Olaparib in the absence or presence of 1 µM CDK1i. Data are presented as the mean±SEM of three independent experiments.