Table 2. Top IPA results for the 471 differential expressed genes (DEGs) identified from the 16L2h:8fwb contrast.
| Top Canonical Pathways | p-value | Overlap* |
|---|---|---|
| Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis | 3.26E-14 | 11.3%, 34/300 |
| HMGB1 Signaling | 3.15E-11 | 15.3%, 20/131 |
| Hepatic Cholestasis | 8.73E-10 | 12.7%, 20/157 |
| Role of Osteoblasts, Osteoclasts and chondrocytes in Rheumatoid Arthritis | 8.80E-10 | 10.6%, 24/227 |
| Hepatic Fibrosis / Hepatic Stellate Cell Activation | 1.87E-09 | 11.6%, 21/181 |
| Top Upstream Regulators | p-value of overlap | Predicted Activation |
| TNF | 4.29E-20 | Activated |
| IL1A | 8.23E-14 | Activated |
| RELA | 1.73E-12 | Activated |
| Jnk (MAPK8) | 1.60E-10 | Activated |
| Top Diseases and Disorders | p-value range | # Molecules |
| Cancer | 9.76E-04 - 4.36E-13 | 428 |
| Organismal Injury and Abnormalities | 9.78E-04 - 4.36E-13 | 434 |
| Dermatological Diseases and Conditions | 5.80E-04 - 1.95E-12 | 267 |
| Reproductive System Disease | 9.69E-04 - 1.55E-10 | 262 |
| Inflammatory Disease | 9.31E-04 - 1.09E-09 | 105 |
| Top Molecular and Cellular Functions | p-value range | # Molecules |
| Cell-To-Cell Signaling and Interaction | 9.76E-04 - 1.83E-12 | 89 |
| Cellular Development | 9.76E-04 - 4.45E-12 | 134 |
| Cellular Movement | 8.70E-04 - 1.26E-11 | 96 |
| Cellular Growth and Proliferation | 9.76E-04 - 3.74E-11 | 148 |
| Lipid Metabolism | 8.38E-04 - 1.53E-08 | 50 |
*Overlap: genes shared between 471 DEGs and genes in a canonical pathway