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. 2017 Aug 27;8(53):90852–90867. doi: 10.18632/oncotarget.20310

Figure 1. GSTA1 Haplotype and Reporter Gene assay of GSTA1 promoter.

Figure 1

A. Haplotypes investigated with luciferase reporter assay. rs (reference SNP ID) numbers correspond to each SNP included for site directed mutagenesis. SNPs used for genotyping and for inferring sub-haplotypes in patients are highlighted in bold. B. Luciferase activities of the proximal promoters of GSTA1 variants (GSTA1*A1, GSTA1*A2, GSTA1*A3, GSTA1*B1a, GSTA1*B2, GSTA1*B1b) in transient transfection in HepG2 cells. Error bars represent the standard deviations. Pairwise comparisons by analysis of variance (ANOVA) between data for the GSTA1*A1 vs. any other haplotype, after Bonferroni correction *** = p < 0.001; ****= p <0.0001, ***** = p < 0.000001.