Table 1. GSTA1 diplotype frequencies in the study population and proposed functional groups.
| GSTA1 Diplotype | Diplotype Frequencies N (%) |
Proposed Functional group |
|---|---|---|
| GSTA1*A2*A2 | 12 (8.7) | I (9.4%) |
| GSTA1*A2*A3 | 1 (0.7) | |
| GSTA1*A2*A1 | 18 (13.0) | II (28.2%) |
| GSTA1*A2*B1a | 11 (8.0) | |
| GSTA1*A2*B2 | 10 (7.2) | |
| GSTA1*A1*A1 | 17 (12.3) | III (47.8%) |
| GSTA1*A1*B1a | 48 (34.8) | |
| GSTA1*A1*B2 | 1 (0.7) | |
| GSTA1*B1b*A2 | 3 (2.2) | IV (14.5%) |
| GSTA1*B1a*B1a | 10 (7.2) | |
| GSTA1*B2*B1a | 1 (0.7) | |
| GSTA1*B1b*A1 | 3 (2.2) | |
| GSTA1*B1a*B1b | 3 (2.2) | |
| Total | 138 (100) |
Abbreviations: GSTA1: glutathione S transferase alpha1. The proposed functional groups arise from in vitro reporter-gene assays and in vivo PK data performed in this study. Group I: considered as rapid metabolizers; Group II: considered as intermediate metabolizers; Group III: considered as normal metabolizers and Group IV: considered as slow metabolizers.