Table 3. Relationship between GST genotypes and the clearance in univariate and multivariate linear regression.
| Variables | p | B | R2 | Model | |
|---|---|---|---|---|---|
| All patients | GSTA1 | 0.009 | -0.31 | 5 | Univariate |
| GSTA1 | 0.01 | -0.27 | 28 | Multivariate | |
| Age | <0.0005 | -0.09 | |||
| Sex | 0.09 | 0.3 | |||
| Girls only | GSTA1 | <0.0005 | -0.54 | 19 | Univariate |
| GSTA1 | 0.006 | -0.35 | 46 | Multivariate | |
| Age | <0.0005 | -0.1 | |||
| Group I and IV | GSTA1 | 0.005 | -0.37 | 23 | Univariate |
| GSTA1 | 0.02 | -0.28 | 42 | Multivariate | |
| Age | 0.004 | -0.1 |
Co-variables include age (continuous), sex (dichotomized), conditioning regimen (busulfan-cyclophophamide vs others) and diagnosis (malignant versus non-malignant); Co-variables with p<0.1 were retained in final model. When all patients and girls only were analyzed, GSTA1 included all 4 diplotype groups; B, unstandardized coefficient, R2, % of variability explained by the genotype or the model (in multivariate analysis).