Table 7. Busulfan pharmacokinetic parameters observed in the study subjects after administration of the first dose.
| Parameter for all centers | Median (range) N=138 |
Median (range) CHUSJ only N=83 |
Median (range) Other cohorts N=55 |
|---|---|---|---|
| Cmax (ng/mL) | 890.5 (515.9-1709) | 844.0 (545.0-1298.0) | 1004.8 (515.9-1709) |
| CSS (ng/mL) | 667.7 (325-1238) | 596.0 (325.0-1227.0) | 711.0 (403.0-1238.0) |
| AUC (mg.h/L) | 3.5 (1.82-7.31) | 3.3 (1.8-7.2) | 4.2 (2.2-7.3) |
| Clearance (mL/min/kg) | 4.1 (1.8-7.2) | 4.2 (1.8-7.2) | 3.7 (1.8-6.3) |
Cmax: maximum plasma concentration; Cmin: Minimum plasma concentration; Css: Steady state plasma concentration; AUC: Area under the curve; CHUSJ: Center Hospitalier universitaire Sainte-Justine