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. 2017 Aug 10;8(53):91281–91290. doi: 10.18632/oncotarget.20108

Figure 3. miR-204-5p suppressed the MMP-13 expression in the chondrocytes.

Figure 3

(A) There is a potential miR-204-5p binding sequence in the 3’UTR of MMP-13 through by using TargetScanHuman miRNA target prediction software. (B) The expression of miR-204-5p in the chondrocytes was measured by qRT-PCR. (C) miR-204-5p decreased the luciferase activity of MMP-13-WT plasmid, but not of MMP-13-Mut, manifesting that MMP-13 was one of miR-204-5p direct targets. (D) Overexpression of miR-204-5p suppressed MMP-13 expression in the chondrocytes. (E) The protein expression of MMP-13 in the chondrocytes was analyzed by western blot. (F) Overexpression of UCA1 promoted the MMP-13 expression in the chondrocytes. **p < 0.01.