Figure 1. Dose-dependent Hep3B cells viability response to sorafenib and melatonin.

Cells were incubated under normoxia (Nx) or hypoxia (Hx) for 48 h in the absence or presence of sorafenib (2.5, 5 or 10 μM) and/or melatonin (1 or 2 mM). Viability was analyzed by MTT. Data are expressed as a percentage of mean values ± SD of experiments performed in triplicate. *p<0.05 vs normoxic or hypoxic non-treated cells.