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. 2017 Sep 16;8(53):91505–91515. doi: 10.18632/oncotarget.21065

Figure 3. VNA titers and protection of rHEP-IL18 in mice.

Figure 3

(A) Groups of 10 ICR mice (n = 10) were respectively immunized with 1 × 104 or 1 × 105 FFU of rHEP-IL18, HEP-Flury or DMEM by the i.m. route. At days 7, 14, 21, 35, 42 and 56 after immunization, the peripheral blood was collected for VNA test. Titers were normalized to IU using the WHO standard. Data are analyzed by one-way ANOVA and asterisks indicate significant differences among the experimental groups (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.001). (B) Then at days 21 after immunization, mice were challenged with 10 × IMLD50 of street rabies virus strain HuNPB3 by the i.m. route and observed daily for 14 days, and survivorship was recorded.