Table 4. CNTF concentrations in the biologic fluids (pg/ml) and the aqueous humor to lacrimal fluid ratio in the main group depending on the POAG stage.
| Biologic fluid | POAG stage |
P / Padj | ||
|---|---|---|---|---|
| 1/2. Early to moderate (n=21) | 3. Advanced (n=18) | 4. Severe (n=16) | ||
| Aqueous humor | ||||
| mean±SD |
44.6±25.9 |
45.2±31.6 |
27.7±14.6 |
NS / |
| mean (adjusted) |
45.3 |
42.7 |
28.2 |
0.028 b |
| range |
4.6–130 |
10.8–135.2 |
3.4–48.8 |
|
| median (IQR) |
41.4 (30.6–54.7) |
38.8 (26.6–46.4) |
25.4 (16–38.1) |
|
| Lacrimal fluid | ||||
| mean±SD |
28.5±14.6 a |
27.5±16.8 |
19.9±11.8 a |
0.041 c / |
| mean (adjusted) |
28.3 |
26.6 |
22.7 |
NS |
| range |
3.2–67.6 |
7.6–84.4 |
4.4–52.8 |
|
| median (IQR) |
28.5 (23.1–35.9) |
23.7 (20–26.3) |
20.0 (13.2–23.8) |
|
| Aqueous humor / lacrimal fluid ratio | ||||
| mean±SD |
1.89±1.47 a |
1.68±0.75 |
1.44±0.62 a |
NS / |
| mean (adjusted) |
1.91 d |
1.58 |
1.49 |
NS |
| range |
0.56–6.88 |
0.45–3.48 |
0.66–2.77 |
|
| median (IQR) |
1.50 (1.28–1.78) |
1.58 (1.28–1.93) |
1.26 (1.07–1.75) |
|
| Blood serum | ||||
| mean±SD |
4.60±2.24 |
6.32±4.01 |
5.78±2.76 |
NS / |
| mean (adjusted) |
3.21 |
5.19 |
4.21 |
NS |
| Maximum |
11.6 |
20.3 |
10.6 |
|
| median (IQR) |
3.90 (2.70–5.60) |
4.80 (3.80–6.60) |
4.50 (3.20–8.00) |
|
| n censored | 5 | 2 | 3 | |
Statistical analysis was performed by Kruskal–Wallis test with post hoc pairwise comparisons by Holm method; CNTF in blood serum was compared by the generalized Wilcoxon test SD – standard deviation; IQR – interquartile range; n censored - number of observations below the minimum quantifiable value 2.5 pg/ml; NS – non-significant; means are adjusted by age, sex, IOP, medical, laser, and surgical treatment; Padj – P for adjusted values a One case excluded with CNTF in lacrimal fluid not examined b Padj 1/2–4=0.010 c P1/2–4=0.017 d Without two extreme outliers, mean±SD=1.43±0.35, mean (adjusted)=1.45.