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. 2018 Jan 1;111:247–256. doi: 10.1016/j.ejps.2017.10.007

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© 2017 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 2. — Statistical comparison of design of experiment equilibrium solubility measurements.

a: Acidic drugs.

Legend: Equilibrium solubility measurements for each drug in full range design of experiment media. Box and whisker plots from top to bottom the maximum value, 75th percentile, median, 25th percentile and minimum value, fasted design of experiment solubility data (Khadra et al., 2015); fed design of experiment solubility data (Zhou et al., 2017). KS statistic value of Kolmogorov normality test on the data set, if p-value is < 0.05 the distribution is non-normal. Mann-Whitney non parametric test determine whether the population medians of two groups differ, not significant (NS) if p-value > 0.05; * if p-value ≤ 0.05; ** if p-value ≤ 0.01; *** if p-value ≤ 0.001 and **** if p-value ≤ 0.0001.

b: Basic drugs.

Legend: Equilibrium solubility measurements for each drug in full range design of experiment media. Box and whisker plots from top to bottom the maximum value, 75th percentile, median, 25th percentile and minimum value, fasted design of experiment solubility data (Khadra et al., 2015); fed design of experiment solubility data (Zhou et al., 2017). KS statistic value of Kolmogorov normality test on the data set, if p-value is < 0.05 the distribution is non-normal. Mann-Whitney non parametric test determine whether the population medians of two groups differ, not significant (NS) if p-value > 0.05; * if p-value ≤ 0.05; ** if p-value ≤ 0.01; *** if p-value ≤ 0.001 and **** if p-value ≤ 0.0001.

c: Neutral drugs.

Legend: Equilibrium solubility measurements for each drug in full range design of experiment media. Box and whisker plots from top to bottom the maximum value, 75th percentile, median, 25th percentile and minimum value, fasted design of experiment solubility data (Khadra et al., 2015); fed design of experiment solubility data (Zhou et al., 2017). KS statistic value of Kolmogorov normality test on the data set, if p-value is < 0.05 the distribution is non-normal. Mann-Whitney non parametric test determine whether the population medians of two groups differ, not significant (NS) if p-value > 0.05; * if p-value ≤ 0.05; ** if p-value ≤ 0.01; *** if p-value ≤ 0.001 and **** if p-value ≤ 0.0001.

Statistical comparison of design of experiment equilibrium solubility measurements.

a: Acidic drugs.

Legend: Equilibrium solubility measurements for each drug in full range design of experiment media. Box and whisker plots from top to bottom the maximum value, 75th percentile, median, 25th percentile and minimum value, fasted design of experiment solubility data (Khadra et al., 2015); fed design of experiment solubility data (Zhou et al., 2017). KS statistic value of Kolmogorov normality test on the data set, if p-value is < 0.05 the distribution is non-normal. Mann-Whitney non parametric test determine whether the population medians of two groups differ, not significant (NS) if p-value > 0.05; * if p-value ≤ 0.05; ** if p-value ≤ 0.01; *** if p-value ≤ 0.001 and **** if p-value ≤ 0.0001.

b: Basic drugs.

Legend: Equilibrium solubility measurements for each drug in full range design of experiment media. Box and whisker plots from top to bottom the maximum value, 75th percentile, median, 25th percentile and minimum value, fasted design of experiment solubility data (Khadra et al., 2015); fed design of experiment solubility data (Zhou et al., 2017). KS statistic value of Kolmogorov normality test on the data set, if p-value is < 0.05 the distribution is non-normal. Mann-Whitney non parametric test determine whether the population medians of two groups differ, not significant (NS) if p-value > 0.05; * if p-value ≤ 0.05; ** if p-value ≤ 0.01; *** if p-value ≤ 0.001 and **** if p-value ≤ 0.0001.

c: Neutral drugs.

Legend: Equilibrium solubility measurements for each drug in full range design of experiment media. Box and whisker plots from top to bottom the maximum value, 75th percentile, median, 25th percentile and minimum value, fasted design of experiment solubility data (Khadra et al., 2015); fed design of experiment solubility data (Zhou et al., 2017). KS statistic value of Kolmogorov normality test on the data set, if p-value is < 0.05 the distribution is non-normal. Mann-Whitney non parametric test determine whether the population medians of two groups differ, not significant (NS) if p-value > 0.05; * if p-value ≤ 0.05; ** if p-value ≤ 0.01; *** if p-value ≤ 0.001 and **** if p-value ≤ 0.0001.