Fig 2. Naloxone reverses oxycodone-induced respiratory depression in vaccinated animals.

Naloxone 0.1 mg/kg s.c. was administered to mice 30 minutes after oxycodone 9.0 mg/kg s.c. SaO₂ recovered promptly in both OXY-dKLH and control groups. SaO₂ did not differ between OXY-dKLH and control groups at any time after naloxone treatment (p = 0.65). Mean ± SEM; n = 11 for KLH and n = 12 for OXY-KLH.