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. 2017 Dec 1;12(12):e0188473. doi: 10.1371/journal.pone.0188473

Fig 1.

Fig 1

(A) Pitx2 and Enpep gene expression in the left (LA) and right (RA) atrial chambers of experimental hyperthyroid rats (HTD) as compared to controls. Observe that Pitx2 and Enpep are significantly decreased in both atrial chambers in HTD hearts. (B) AF GWAS-associated gene expression in the LA chamber of HTD hearts. Wnt8 and Wnt11 are significantly increased whereas Zfhx3 and Kcnn3 are decreased in HTD hearts as compared to controls. (C) Ion channel encoding genes display significant differential expression in HTD as compared to controls, while Camk2a display no significant differences. (D) Pitx2-regulated microRNAs display significant increased expression in HTD as compared to controls. In all cases, n = 6.*p<0.01, **p<0.05, ***p<0.001,****p<0.0001.